Dr Holland has been awarded a highly prestigious Brain fellowship to study the impact of PSP and CBS on synapses using PET.
Dr Negin Holland will undertake her PhD here thanks to a 3 year fellowship from the Guarantors of Brain. With an academic clinical fellowship in Neurology, she has already made a substantial contribution to research at the Center for Frontotemporal Dementia, but moves to the Foundational Clinical Research program at the Cambridge Centre for Parkinson Plus, to study the impact of Progressive Supranuclear Palsy and Corticobasal degeneration on synapses. using a new PET ligand, she will show how PSP and CBS reduce synaptic density, even very early in the disease, and how this leads to symptoms. Synaptic density, and synaptic plasticity, are potentially reversible parts of the pathology of neurodegenerative disease, giving new hop for treatments in the future.