Dr Negin Holland

I completed my PhD in 2021, assessing in vivo synaptic loss in the neurodegenerative primary tauopathies using [11C]UCB-J PET/MRI imaging. In a series of publications, I illustrated significant synaptic loss in these neurological disorders, which was progressive over one year, and correlated with the underlying tau pathology, and the patients’ cognitive performance. This work however highlighted that patients significantly vary in their rate of synaptic loss over time. My clinical lectureship therefore focuses on understanding this heterogeneity in primary tauopathies, using disease modelling with multimodal neuroimaging (PET and MRI), and blood biomarkers as input parameters. Alongside my research, I am also a neurology registrar in the East of Anglia Deanery, striving to combine a research and clinical career as an academic neurologist.